MASCIS Impactor, NYU Impactor）脊髓沖擊損傷動(dòng)物模型打擊器Multicenter Animal Spinal Cord Injury Study是設(shè)計(jì)用來(lái)為大小鼠施加可重復(fù)的標(biāo)準(zhǔn)脊椎撞擊。已經(jīng)開發(fā)應(yīng)用超過(guò)十年，它是嚙齒類動(dòng)物脊髓損傷模型的一部分，已經(jīng)有超過(guò)100個(gè)實(shí)驗(yàn)室在使用它。另外，zui近超過(guò)50%的關(guān)于脊髓損傷研究文獻(xiàn)使用的是MASCIS撞擊器。大部分儀器的建議操作程序是源自于Multicenter Animal Spinal Cord Injury Study（MASCIS）模型和實(shí)際工作經(jīng)驗(yàn)。      現(xiàn)有MASCIS撞擊器現(xiàn)在是它的第三代產(chǎn)品，與以前的產(chǎn)品相比已經(jīng)有很多方面的改進(jìn)提高。現(xiàn)有兩個(gè)型號(hào)的撞擊器。電腦版撞擊器可以記錄數(shù)據(jù)。同時(shí)也可以使用基本版撞擊器（The Rutgers Impactor）僅進(jìn)行撞擊， 不記錄數(shù)據(jù)。      電腦版撞擊器可以精確測(cè)量一個(gè)10克的小棒的運(yùn)動(dòng)情況，這個(gè)小棒從12.5mm，25mm，50mm高處落到術(shù)后暴露的脊髓T9-10處。另外設(shè)備還可以測(cè)量撞擊位置脊柱的運(yùn)動(dòng)。顯示墜落小棒的軌跡，并測(cè)量撞擊速度（ImpV），脊髓壓縮距離（Cd），脊髓壓縮時(shí)間（Ct），脊髓壓縮率（Cr）。這些撞擊參數(shù)本身是相關(guān)的，同時(shí)與其它的脊髓損傷數(shù)值如組織Na，K濃度，運(yùn)動(dòng)恢復(fù)locomotor recovery（BBB 評(píng)分）也是相關(guān)的. MICFORCE米力光CO.LTD

The MASCIS Impactor is a device designed to deliver graded reproducible spinal cord contusions in rats. Developed over ten years ago, the Impactor is part of a well-defined rodent spinal cord injury model that is used in over 100 laboratories around the world. In addition, more than 50% of recent publications on spinal cord injury research used the MASCIS Impactor. Most of the recommended procedures for the Impactor are based on experience with the model and work done by the Multicenter Animal Spinal Cord Injury Study （MASCIS）. 

The Impactor is now in its third generation with many improvements over previous models. It is available in a model with data recording capability （description and picture links） which requires a Pentium computer. It is also available in a basic model （The Rutgers Impactor） which only does the impact, not the recording of data.

Clamping systems are available for both rat and mouse.  A clamping system is necessary for the Rutgers basic model and serves as a functional enhancement for the MASCIS model.  （description and picture.）  When using a clamping system with the MASCIS model, a CS-tie device also is needed.

The MASCIS Impactor, formerly called the NYU Impactor, was developed in 1991 by Drs. John

Gruner, Carl Mason, and Wise Young. It is now used in laboratories throughout the world in their

spinal cord injury studies. The device precisely measures the movement of a 10-gram rod

dropped 12.5, 25.0, or 50.0 mm onto the T9-10 spinal cord exposed by laminectomy. In

addition, the device measures movement of the spinal column at the impact site, displays the

trajectory of the falling rod, and measures the impact velocity （ImpV）, cord compression

distance （Cd）, cord compression time （Ct）, and cord compression rate （Cr）. These impact

parameters correlate with each other and spinal cord lesion volumes （estimated from tissue Na

and K concentrations） and locomotor recovery （BBB scores）.

1:Serial changes in bladder, locomotion, and levels of neurotrophic factors in rats with spinal cord contusion.

Hyun JK, Lee YI, Son YJ, Park JS.
Department of Rehabilitation Medicine, Dankook University, Cheonan, Korea. rhhyun@dankook.ac.kr

2:A re-assessment of minocycline as a neuroprotective agent in a rat spinal cord contusion model.

Pinzon A, Marcillo A, Quintana A, Stamler S, Bunge MB, Bramlett HM, Dietrich WD.
Brain Res. 2008 Dec 3;1243:146-51. Epub 2008 Sep 24.

3 :The role of cation-dependent chloride transporters in neuropathic pain following spinal cord injury.

Cramer SW, Baggott C, Cain J, Tilghman J, Allcock B, Miranpuri G, Rajpal S, Sun D, Resnick D.
Mol Pain. 2008 Sep 17;4:36.

4:Novel combination strategies to repair the injured mammalian spinal cord.

Bunge MB.
J Spinal Cord Med. 2008;31（3）:262-9. Review.

5:A re-assessment of erythropoietin as a neuroprotective agent following rat spinal cord compression or contusion injury.

Pinzon A, Marcillo A, Pabon D, Bramlett HM, Bunge MB, Dietrich WD.
Exp Neurol. 2008 Sep;213（1）:129-36. Epub 2008 Jul 14.

6: B1 and TRPV-1 receptor genes and their relationship to hyperalgesia following spinal cord injury.
DomBourian MG, Turner NA, Gerovac TA, Vemuganti R, Miranpuri GS, Türeyen K, Satriotomo I, Miletic V, Resnick DK.
Spine. 2006 Nov 15;31（24）:2778-82.

7:Endothelial cell loss is not a major cause of neuronal and glial cell death following contusion injury of the   spinal cord.
Casella GT, Bunge MB, Wood PM.
Exp Neurol. 2006 Nov;202（1）:8-20. Epub 2006 Jul 26.

8:Recovery of function following grafting of human bone marrow-derived stromal cells into the injured spinal cord.
Himes BT, Neuhuber B, Coleman C, Kushner R, Swanger SA, Kopen GC, Wagner J, Shumsky JS, Fischer I.
Neurorehabil Neural Repair. 2006 Jun;20（2）:278-96.

9:Mechanical and cold allodynia in a rat spinal cord contusion model.
Yoon YW, Dong H, Arends JJ, Jacquin MF.
Somatosens Mot Res. 2004 Mar;21（1）:25-31.

10:Spinal cord contusion models.
Young W.
Prog Brain Res. 2002;137:231-55. Review.