Anti-AGER/RAGE抗體,晚期糖基化終末產物特異性受體抗體產品詳細資料

產品編號 BYK-0177R

英文名稱 RAGE/MOK protein kinase
中文名稱 晚期糖基化終末產物特異性受體抗體
別    名 Advanced glycosylation end product specific receptor; Advanced glycosylation end product-specific receptor; AGER; EC 2.7.11.22; LE 9211 A antigen;LE-9211-A antigen; MGC22357; MOK; RAGE 1; RAGE1; MOK protein kinase; Receptor for advanced glycation endproducts;Renal tumor antigen 1; Renal tumor antigen; Renal cell carcinoma antigen (MOK protein kinase); Renal tumor antigen 1; RAGE_HUMAN.
研究領域 腫瘤  心血管  免疫學  生長因子和激素  糖尿病  內分泌病  
分 子 量 42kDa
細胞定位 細胞膜 分泌型蛋白 

抗體來源 Mouse or Rabbit
克隆類型 Monoclonal or Polyclonal
產品應用 WB、ELISA、IHC-P、IHC-F、Flow-Cyt、IF、IP、ICC 此產品應用不做依據(jù)，具體產品應用與實驗稀釋比請！

not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
亞    型 IgG
純化方法 affinity purified by Protein G
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.


     Anti-AGER/RAGE抗體,晚期糖基化終末產物特異性受體抗體產品介紹 

      Advanced glycosylation end product-specific receptor (AGER; RAGE) is a member of the immunoglobulin superfamily of cell surface molecules that binds molecules that have been irreversibly modified by non-enzymatic glycation and oxidation, and are know as advanced glycation end products (AGEs). It is expressed by endothelium, mononuclear phagocytes, neurons and smooth muscle cells. Whereas RAGE is present at high levels during development, especially in the central nervous system, its levels decline during maturity.The increased expression of RAGE is associated with several pathological states, such as diabetic vasculopathy, neuropathy, retinopathy and other disorders, including Alzheimer's disease and immune/inflammatory reactions of the vessel walls. In diabetic tissues, the production of RAGE is due to the overproduction of AGEs that eventually overwhelm the protective properties of RAGE. This results in oxidative stress and endothelial cell dysfunction that leads to vascular disease in diabetics. In the brain, RAGE also binds amyloid beta (Ab). Because Ab is overproduced in neurons and vessels in the brains of Alzheimer disease, this leads to the hyperstimulation of RAGE. The RAGE-Ab interaction is thought to result in oxidative stress leading to neuronal degeneration.

     相關產品：

     Anti-FRMD1抗體,FRMD1蛋白抗體

Anti-FAM40A抗體,FAM家族蛋白40A抗體
Anti-FAM120B抗體,組織激活過氧化酶活化增生受體γ蛋白抗體
Anti-FAM55D抗體,FAM55D蛋白抗體
Anti-FAM46C抗體,FAM46C蛋白抗體
Anti-TCRP1抗體,舌癌*耐藥相關蛋白1抗體
Anti-FAM129B抗體,FAM129B蛋白抗體
Anti-RMD2抗體,微管動力調節(jié)蛋白2抗體
Anti-FAM50A抗體,FAM50A蛋白抗體
Anti-FAM113A抗體,FAM113A蛋白抗體
Anti-FAM21C抗體,FAM21C蛋白抗體
Anti-FAM13C1抗體,FAM13C1蛋白抗體
Anti-FAM161A抗體,FAM161A蛋白抗體
Anti-FAM59B抗體,FAM59B蛋白抗體
Anti-FAM59A抗體,FAM59A蛋白抗體
Anti-FAM150A抗體,FAM150A蛋白抗體
Anti-FAM151A抗體,FAM151A蛋白抗體