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M60082-2s

SCR7, NHEJ inhibitor

2 mg solid

Xcessbio Biosciences

SCR7, NHEJ inhibitor

A potent and selective inhibitor of non-homologous end joining (NHEJ).

Catalog No.	Unit	Price	Qty
M60082-2s	2 mg solid
M60082-2	10 mM DMSO (0.598 mL)

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Product Information

Molecular Weight:	334.39
Formula:	C18H14N4OS
Purity:	≥ 98%
Solubility:	DMSO up to 50 mM
Chemical Name:	5,6-bis((E)-benzylideneamino)-2-mercaptopyrimidin-4-ol
Storage:	Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year

Biological Activity:

SCR7 is a potent and selective inhibitor of non-homologous end joining (NHEJ). It inhibits joining of DSBs in cell-free DNA repair system, blocks Ligase IV-mediated joining by interfering with its DNA binding but not that of T4 DNA Ligase or Ligase I, thereby leading to accumulation of DSBs within the cells, culminating into cytotoxicity. SCR7 inhibits NHEJ in a Ligase IV-dependent manner within cells, and activates the intrinsic apoptotic pathway. More importantly, SCR7 impedes tumor progression in mouse models, and when co-administered with DSB-inducing therapeutic modalities it enhances their sensitivity significantly. SCR7 to target NHEJ offers a novel strategy toward the treatment of cancer and improvement of existing regimens.

How to Use:

In vitro: SCR7 was used at 20-150 μM final concentration in vitro and in cellular assays.
In vivo: SCR7 was intraperitoneally (IP) dosed to mice at 20 mg/kg once per day.
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