Xcessbio Biosciences代理，Xcessbio Biosciences中國代理，Xcessbio Biosciences代理，Xcessbio Biosciences上海代理，Xcessbio Biosciences北京代理，Xcessbio Biosciences廣州代理，Xcessbio Biosciences，Xcessbio 代理，Xcessbio代理，Xcessbio代理，M60082-2s代理，M60082-2s，M60082-2s

M60082-2s

SCR7, NHEJ inhibitor

2 mg solid

Xcessbio Biosciences

SCR7, NHEJ inhibitor

A potent and selective inhibitor of non-homologous end joining (NHEJ).

Catalog No.	Unit	Price	Qty
M60082-2s	2 mg solid
M60082-2	10 mM DMSO (0.598 mL)

Add To Cart

Bulk Request

Description
Reviews

Product Information

Molecular Weight:	334.39
Formula:	C18H14N4OS
Purity:	≥ 98%
Solubility:	DMSO up to 50 mM
Chemical Name:	5,6-bis((E)-benzylideneamino)-2-mercaptopyrimidin-4-ol
Storage:	Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year

Biological Activity:

SCR7 is a potent and selective inhibitor of non-homologous end joining (NHEJ). It inhibits joining of DSBs in cell-free DNA repair system, blocks Ligase IV-mediated joining by interfering with its DNA binding but not that of T4 DNA Ligase or Ligase I, thereby leading to accumulation of DSBs within the cells, culminating into cytotoxicity. SCR7 inhibits NHEJ in a Ligase IV-dependent manner within cells, and activates the intrinsic apoptotic pathway. More importantly, SCR7 impedes tumor progression in mouse models, and when co-administered with DSB-inducing therapeutic modalities it enhances their sensitivity significantly. SCR7 to target NHEJ offers a novel strategy toward the treatment of cancer and improvement of existing regimens.

How to Use:

In vitro: SCR7 was used at 20-150 ?M final concentration in vitro and in cellular assays.
In vivo: SCR7 was intraperitoneally (IP) dosed to mice at 20 mg/kg once per day.
Xcessbio Biosciences代理，Xcessbio Biosciences中國代理，Xcessbio Biosciences代理，Xcessbio Biosciences上海代理，Xcessbio Biosciences北京代理，Xcessbio Biosciences廣州代理，Xcessbio Biosciences，Xcessbio 代理，Xcessbio代理，Xcessbio代理，M60082-2s代理，M60082-2s，M60082-2s

歡迎下載下面的資料以了解此產(chǎn)品的相關(guān)信息！預(yù)詢產(chǎn)品訂購信息

上海普邁生物致力于提供高質(zhì)量的產(chǎn)品和服務(wù)組織形態(tài)學(xué)研究與競爭力的產(chǎn)品
產(chǎn)品和服務(wù),有相關(guān)產(chǎn)品的問題請直接
期貨每周下午5點(diǎn)前發(fā)定單，正常到上海時(shí)間為3-4周
現(xiàn)市區(qū)2天內(nèi)送到，外地以快遞為準(zhǔn)
敬請關(guān)注！
：
:pumaibio。。ｃｏｍ
:pumaibio
:（直接客戶）
（經(jīng)銷商）
*etonbio、polysciences、Mattek、trevigen、Chromogenix、cyguns、IrvineScientific、Innovative Cell Technologies、enzo、novus、immunochemistry、eylabs、Polyplus、NIBSC、ALZET、hitobiotec、sutter instrument、mirus、StressMarq、Avanti、jena bioscience、Neuro Probe、tedpella、avanti、Rockland、CAYMAN、transgenomic、BioLegend、ambion、omicronbio、
Assaybiotech、chondrex、lc?laboratories、cosmobio、megazyme、NeoMarkers、BTI、eylabs、berryassoc、cellagentech、TOCRIS、Relia Tech、SouthernBiotech、Biosearch technology、Lumiprobe、StemCells?Inc、biovendor、NORGEN、alomone、jena?bioscience、Gracebio、Eurogentec、Gelcompany?、invitrogen、gene?bridges、MRC-Holland、laysanbio