肝羧酸酯酶1抗體,Anti-CES1抗體簡(jiǎn)單介紹：

產(chǎn)品編號(hào)：BYK-18301R

英文名稱：Anti-CES1
中文名稱：肝羧酸酯酶1抗體

別名：ACAT; Acyl coenzyme A cholesterol acyltransferase; Acyl-coenzyme A:cholesterol acyltransferase; Brain carboxylesterase hBr1; Carboxyesterase ES-3; Carboxylesterase; Carboxylesterase 1 (monocyte/macrophage serine esterase 1); Carboxylesterase 1; Carboxylesterase 1 deficiency, included; Carboxylesterase 2, formerly; CE 1; CEH; Ces-1; Ces1; CES2; CESDD1; Cholesterol ester hydrolase, neutral, macrophage-derived; Cholesteryl ester hydrolase; Cocaine carboxylesterase; EC 3.1.1.1; Egasyn; ES-H; ES-x; Es22; EST1_HUMAN; Esterase 22; Esterase; hCE 1; HMSE; HMSE1; Liver carboxylesterase 1; Liver carboxylesterase 3; Methylumbelliferyl acetate deacetylase 1; MGC117365; MGC156521; Monocyte carboxylesterase deficiency, included; Monocyte esterase deficiency, included; Monocyte/macrophage serine esterase; PCE-1; pI 5.5 esterase; Proline-beta-naphthylamidase; REH; Retinyl ester hydrolase; Serine esterase 1; Ses-1; SES1

背景介紹：This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. 

產(chǎn)品規(guī)格：50ul；100ul；200ul；1ml，*

抗體來(lái)源 Rabbit or Mouse

克隆類型 Polyclonal or Monoclonal

交叉反應(yīng)、產(chǎn)品應(yīng)用 （具體交叉反應(yīng)與產(chǎn)品應(yīng)用請(qǐng)或添加客服直接索取）

性    狀 Lyophilized or Liquid
濃    度 1mg/ml

肝羧酸酯酶1抗體,Anti-CES1抗體產(chǎn)品信息：

免疫應(yīng)答

    抗原刺激機(jī)體產(chǎn)生相應(yīng)的抗體，抗體的產(chǎn)生過(guò)程即為體液免疫應(yīng)答過(guò)程。

    體液免疫應(yīng)答的主要*位是淋巴結(jié)、脾臟和粘膜下淋巴組織等外周免疫器官，外來(lái)抗原進(jìn)入機(jī)體后即被補(bǔ)體致敏或者被DC吞噬，然后隨淋巴液進(jìn)入引流淋巴結(jié)。淋巴濾泡中的FDC通過(guò)其表面的補(bǔ)體受體捕獲被致敏的外來(lái)抗原，激活B細(xì)胞。位于脾髓質(zhì)交界區(qū)的DC則為T細(xì)胞呈遞外來(lái)抗原肽，啟動(dòng)獲得性免疫應(yīng)答，B細(xì)胞在外周成熟、發(fā)育過(guò)程的zui后階段是成為專門的合成和分泌抗體分子的漿細(xì)胞。漿細(xì)胞高爾基體發(fā)達(dá)、代謝活躍，但沒(méi)有繼續(xù)分裂、增殖的能力，也不參與抗原遞呈。他們寄居在脾臟或者骨髓中，集中所有的能量生產(chǎn)并分泌抗體分子?？贵w分子的重鏈和輕鏈在內(nèi)質(zhì)網(wǎng)上合成、組裝后經(jīng)高爾基體運(yùn)輸至細(xì)胞表面并分泌于胞外。一個(gè)漿細(xì)胞每秒鐘能分泌5000個(gè)抗體分子，在外周的漿細(xì)胞壽命僅為幾天，但是骨髓中的漿細(xì)胞壽命可能較長(zhǎng)。

免疫應(yīng)答過(guò)程：

1.抗原進(jìn)入機(jī)體；

2.抗原刺激 B淋巴細(xì)胞，使之分化增殖成為抗體分泌漿細(xì)胞和記憶細(xì)胞（初次免疫應(yīng)答）；

3.抗體主要由漿細(xì)胞分泌 ；

4.記憶細(xì)胞再次受到特異性抗原刺激后會(huì)被激活而成為分泌抗體的漿細(xì)胞（再次免疫應(yīng)答）；

5.記憶B細(xì)胞是長(zhǎng)命細(xì)胞，可以存活數(shù)月甚至機(jī)體終生

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