Anti-AT2R抗體，血管緊張素Ⅱ受體1抗體產品詳細資料

產品編號 BYK-0438R

英文名稱 AT2R
中文名稱 血管緊張素Ⅱ受體1抗體
別    名 AG2S; Agtr 1; Agtr1; AGTR1_HUMAN; Agtr1a; AGTR1B; Ang II; Angiotensin II receptor type 1; Angiotensin II type 1 receptor; Angiotensin II type-1 receptor; Angiotensin receptor 1; Angiotensin receptor 1B; AT 1B; AT 1r; AT-1B; AT-1r; AT1; At1a; AT1AR; AT1B; AT1BR; AT1R; AT2R1; AT2R1A; AT2R1B; HAT1R; Type 1 angiotensin II receptor; Type 1B angiotensin II receptor; Type-1 angiotensin II receptor.
研究領域 腫瘤  心血管  細胞生物  免疫學  血管內皮細胞  
分 子 量 41kDa
細胞定位 細胞膜 

抗體來源 Mouse or Rabbit
克隆類型 Monoclonal or Polyclonal
產品應用 WB、ELISA、IHC-P、IHC-F、Flow-Cyt、IF、IP、ICC 此產品應用不做依據，具體產品應用與實驗稀釋比請！

not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
亞    型 IgG
純化方法 affinity purified by Protein G
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.


     Anti-AT2R抗體，血管緊張素Ⅱ受體1抗體產品介紹 

      Angiotensin II (Ang II) is an important physiological effector of blood pressure and volume regulation through vasoconstriction, aldosterone release, sodium uptake and thirst stimulation. Although Ang II interacts with two types of cell surface receptors, AT1 and AT2, most of the major cardiovascular effects seem to be mediated through AT1. Molecular cloning of the AT1 protein has shown it to be a member of the G protein-associated seven transmembrane protein receptor family. Ang II treatment of cells results in activation of several signal transduction pathways as evidenced by tyrosine phosphorylation of several proteins and induction of others. PLC?is phosphorylated after 30 seconds of treatment with Angiotensin II, indicating this as an early signal transduction event. Ang II treatment also stimulates phosphorylation of Shc, FAK and MAP kinases, and induces MKP-1, indicating stimulation of growth factor pathways. Ang II stimulation through AT1 has been shown to activate the JAK/Stat pathway involving a direct interaction between JAK2 and AT1 as demonstrated by coimmunoprecipitation. The AT1 receptor has no cytoplasmic kinase domain, but is able to function as a substrate for Src kinases and has several putative phosphorylation sites.

     相關產品：

     Anti-FAM153B抗體,FAM153B蛋白抗體

Anti-FAM154A抗體,FAM154A蛋白抗體
Anti-FAM155A抗體,FAM155A蛋白抗體
Anti-FAM156A抗體,跨膜蛋白29抗體
Anti-FAM160B1抗體,FAM160B1蛋白抗體
Anti-FAM161B抗體,FAM161B蛋白抗體
Anti-FAM164B抗體,FAM164B蛋白抗體
Anti-FAHD2A抗體,延胡索酰乙酰乙酸水解酶抗體
Anti-FAM101A抗體,FAM101A蛋白抗體
Anti-FAM102B抗體,FAM102B蛋白抗體
Anti-FAM104B抗體,FAM104B蛋白抗體
Anti-FRMD3抗體,FRMD3蛋白抗體
Anti-FRMD4A抗體,FRMD4A蛋白抗體
Anti-FRMD4B抗體,FRMD4B蛋白抗體
Anti-FRMD5抗體,FRMD5蛋白抗體
Anti-FRMD6抗體,FRMD6蛋白抗體
Anti-FRMD7抗體,FRMD7蛋白抗體
Anti-FAM82A1抗體,微管動力調節(jié)蛋白FAM82A抗體