Anti-TERT抗體,端粒酶逆轉(zhuǎn)錄酶抗體說(shuō)明書(shū)產(chǎn)品詳細(xì)資料

產(chǎn)品編號(hào) BYK-1411R

英文名稱(chēng) TERT
中文名稱(chēng) 端粒酶逆轉(zhuǎn)錄酶抗體
別    名 EST2; hEST2; TCS1; omerase associated protein 2; omerase Catalytic Subunit; omere Reverse Transcriptase; omerase reverse transcriptase; TERT; TP2; TRT; TERT_HUMAN; omerase reverse transcriptase; HEST2; omerase catalytic subunit; omerase-associated protein 2.
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  細(xì)胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  
分 子 量 124kDa
細(xì)胞定位 細(xì)胞核 細(xì)胞漿  

抗體來(lái)源 Mouse or Rabbit
克隆類(lèi)型 Monoclonal or Polyclonal
產(chǎn)品應(yīng)用 WB、ELISA、IHC-P、IHC-F、Flow-Cyt、IF、IP、ICC 此產(chǎn)品應(yīng)用不做依據(jù)，具體產(chǎn)品應(yīng)用與實(shí)驗(yàn)稀釋比請(qǐng)！

not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
亞    型 IgG
純化方法 affinity purified by Protein G
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.


     Anti-TERT抗體,端粒酶逆轉(zhuǎn)錄酶抗體說(shuō)明書(shū)產(chǎn)品介紹 

      omerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates omeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. omerase are large DNA-protein complexes with omerase expression being the subject of recent research due to its link to cell immortalization. Recent evidence has shown that MYC upregulates the catalytic subunit of omerase, TERT, and that omerase is a ribonucleoprotein polymerase that maintains omere ends by addition of the omere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the omere repeat. omerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of omeres. Deregulation of omerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that omerase also participates in chromosomal repair, since de novo synthesis of omere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of omerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of omerase activity.

 此相關(guān)標(biāo)記有：Alexa Fluor 350 標(biāo)記、Alexa Fluor 488 標(biāo)記、Alexa Fluor 555 標(biāo)記、Alexa Fluor 647 標(biāo)記、AP標(biāo)記、APC標(biāo)記、Biotin標(biāo)記、Cy3標(biāo)記、Cy5標(biāo)記、Cy5.5標(biāo)記、Cy7標(biāo)記、FITC標(biāo)記、Gold標(biāo)記、HRP標(biāo)記、PE標(biāo)記、PE-Cy3標(biāo)記、PE-CY5標(biāo)記、PE-CY5.5標(biāo)記、PE-CY7標(biāo)記、RBITC標(biāo)記 

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