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熒光胺號：38183-12-9   
英文名稱：Fluorescamine；Fluram；4-Phenylspiro[furan-2(3H),1′(3′H)-isobenzofuran]-3,3′-dione；4-Phenylspiro-[(furan-2(3H),1′-phthalan]-3,3′-dione ,Ro-20-7234    
其他名稱：熒胺；弗路蘭；氟路蘭；4-苯基螺[呋喃-2(3H),1-二氫異苯并呋喃]-3,3'-二酮；4-苯基螺-[呋喃-2(3H),1-哌啶]-3,3′-二酮   
號：38183-12-9    
C17H10O4=278.26   
級別：BioChemika   
純度：≥98.0%   
Lambda max.：233.0～235.0 nm(Diethyl ether)   
熔點：155～159℃   
溶解性：acetonitrile: soluble；ethanol: soluble   
性狀(以下信息僅供參考)：類白色或淺黃色粉末，對濕敏感。本身與水解產(chǎn)物不顯熒光，但與含有伯氨基的化合物(包括蛋白質(zhì)、肽、氨基酸及其他各種多肽)分別生成類似的、具有強烈熒光性的化合物。生成物的Z大激發(fā)波長為390nm，Z大發(fā)射波長為475nm。   
用途：本品僅供科研，不得用于其它用途。(以下用途僅供參考)非熒光試劑，能在溫和的條件下和氨基酸和蛋白質(zhì)的伯氨基形成穩(wěn)定、高熒光、低背景的復合物，用于熒光檢測氨基酸、蛋白質(zhì)和蛋白水解酶。也用于蛋白測序分析中。   
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產(chǎn)品介紹 NELF-A (negative elongation factor A), NELF-B, NELF-C, NELF-D and NELF-E are components of the NELF complex, which is a a structure that negatively regulates Pol II-dependent transcription elongation. Control of transcription elongation requires a complex interplay between positive transcription elongation factor b (P-TEFb) and negative transcription elongation factors, DSIF and NELF. DSIF and NELF, act as negative transcription elongation factors by increasing the time the polymerase spends at pause sites. DSIF/NELF inhibition of transcription is prevented by P-TEFb in cooperation with FACT.
Function : Couples NMDA receptor signaling to the nucleus. Influences outgrowth of olfactory axons and migration of LHRH neurons.
Subunit : Interacts with CABP1 and KPNA1
Subcellular Location : Cell membrane. Nucleus. Found on the outside of the LHRH cell membrane and axons projecting from the olfactory pit and epithelium. Myristoylation is a prerequisite for extranuclear localization.
Tissue Specificity : Highly expressed in adult and fetal brain, testis and kidney.
DISEASE : Defects in NELF may be associated with idiopathic hypogonadotropic hypogonadism (IHH) [MIM:146110]. IHH is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function.
Database links : UniProtKB/Swiss-Prot: Q6X4W1.1
英文名稱  Anti-NELL1
中文名稱  蛋白激酶C結(jié)合蛋白NELL1抗體
別    名  IDH3GL; NEL like protein 1; Nel related protein 1; NEL-like protein 1; Nel-related protein 1; Nell1; NELL1_HUMAN; Neural epidermal growth factor like 1; NRP1; Protein kinase C binding protein NELL1; Protein kinase C-binding protein NELL1.
濃    度  1mg/1ml
規(guī) 格  0.2ml/200μg
抗體來源  Rabbit 
克隆類型  polyclonal
交叉反應  Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep
產(chǎn)品類型  一抗   
研究領(lǐng)域  細胞生物 神經(jīng)生物學 信號轉(zhuǎn)導 生長因子和激素 激酶和磷酸酶 
蛋白分子量  predicted molecular weight: 87kDa
性    狀  Lyophilized or Liquid
免 疫 原  KLH conjugated synthetic peptide derived from human NELL1
亞    型  IgG
純化方法  affinity purified by Protein A
儲 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產(chǎn)品應用   ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500
（石蠟切片需做抗原修復）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user. 
保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介紹 NELL1 is an 810 amino acid secreted protein that contains one TSP N-terminal domain, five VWFC domains and six EGF-like domains. Expressed in craniofacial anomalies, NELL1 exists as a homotrimer that interacts with PKC Beta and is involved in the regulation of cell growth and differentiation. Human NELL1 shares 50% amino acid identity with its chicken counterpart, suggesting that NELL1 may have a conserved role between species. The gene encoding NELL1 maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11.
Function : Involved in the control of cell growth and differentiation.