果蠅作為經(jīng)濟實用的模式動物，可用于中樞神經(jīng)系統(tǒng)紊亂、炎癥性病變、心血管疾病、癌癥以及糖尿病等治療研究，而這些疾病的發(fā)生從生理上來說都與生物個體*的代謝功能異常密切相關(guān)。

MAVEn™高通量16通道果蠅代謝監(jiān)測系統(tǒng)是的美國Sable Systems International動物代謝測量公司生產(chǎn)的一款16通道、高分辨率及自動化的果蠅代謝監(jiān)測儀器，可廣泛用于代謝紊亂造成的各種流行疾病治療的機理研究。

MAVEn™果蠅代謝系統(tǒng)作為果蠅代謝分型監(jiān)測方面的產(chǎn)品，主要具備以下特點：

1. 改變了傳統(tǒng)的單只果蠅的封閉或半封閉式測量模式，實現(xiàn)每個測量室都有實時氣流通過的*開放式測量，避免了測量時內(nèi)出現(xiàn)缺氧（hypoxia）或高碳酸血癥（hypercapnia），可一次測量多達(dá)16只個體。

2. 15秒就可以完成一只果蠅的代謝監(jiān)測，這代表了目前技術(shù)的水平。

3. 數(shù)據(jù)可以通過SD卡把帶時間標(biāo)簽的CSV格式直接導(dǎo)出到電腦。

4. 可選配FLIC果蠅覓食、AD-2果蠅活動、氣體（氧氣、二氧化碳、水汽以及其它可檢測氣體）等監(jiān)測單元。

5. 參考文獻*多，高達(dá)4萬多篇，屬于前沿科技。

具體性能指標(biāo)：

1. 氣流流速：5毫升/分鐘-200毫升/分鐘，質(zhì)量流量計，PID精確控制，精度為2%。

2. 昆蟲測量時間：15秒-3小時可程序化選擇；基線測量時間：15秒-3小時可程序化選擇。

3. 氣壓測量：分辨率1Pa,精度0.05%。

4. 光照水平：0.1-5000勒克斯。

5. 溫度測量：0-50℃，分辨率0.01℃，精度±0.25℃。

6. 模擬輸入：6個模擬輸入，16bit分辨率，-5至+5伏電壓信號，可接SSI其它儀器或?qū)嶒炇移渌鼩怏w分析儀等。

7. 數(shù)據(jù)格式：CSV格式；數(shù)據(jù)存儲：SD卡，*支持32G的SD卡。

8. 雙通道高精度差分式氧氣分析測量儀：測量技術(shù)：燃料電池原理氧氣傳感器，雙通道；氧氣濃度量程0-*（用戶可自定義設(shè)置5個級別）；差值量程±50%；精度0.1%（O2濃度2-*時）；分辨率0.0001%O2；漂移< 0.01%每小時（溫度恒定情況下）；響應(yīng)時間小于7秒；24小時漂移<0.01%；20分鐘噪音<3ppm RMS；數(shù)字過濾（噪音）0-40秒可調(diào)，增幅0.2秒，內(nèi)置A/D轉(zhuǎn)換器分辨率16bits；溫度、壓力補償；傳感器溫度測量范圍0-60℃，精度0.2℃，分辨率0.001℃；大氣壓測量分辨率0.0001kPa，精度為滿量程的0.05%；適用流量范圍5-2000mL/min；4通道模擬信號輸出（0-5V BNC）可輸出通道1的氧氣濃度，通道2的氧氣濃度，1和2的差值，大氣壓；數(shù)字輸出：RS-232；具4行文字LCD顯示屏，帶背光，可同時顯示2個通道的氧氣含量和它們的差值，以及大氣壓；*PID（Proportional-Integral-Derivative）溫控單元，保證內(nèi)部氧氣傳感器溫度恒定，進一步提高了氧氣測量的精度和穩(wěn)定性；供電12-24VDC，8A，配交流電適配器；工作溫度：5-45℃，無冷凝；重量6.4kg；尺寸43.2cm×35.6cm×20.3cm

9. 超高精度二氧化碳分析測量儀：用于測量微小昆蟲（比如果蠅、蚊子等）或蜱螨類微小動物的呼吸代謝，可同時測量CO2濃度和H2O濃度；CO2量程0-3000ppm；準(zhǔn)確度<1%；分辨率0.01ppm；H2O量程0-60mmol/mol；準(zhǔn)確度1%；

10. 二次抽樣單元：內(nèi)置氣泵、精密針閥、質(zhì)量流量計，可用來給氣流樣本做二次抽樣，也可單獨作為氣源使用；流量范圍5-2000mL/min；精度為讀數(shù)的10%；分辨率1mL/min；具備2行顯示LCD顯示屏；帶0-5V BNC模擬信號輸出；數(shù)字輸出RS-232；供電12-15VDC，20-350mA，配交流電適配器；工作溫度：0-50℃，無冷凝；重量1.5kg；尺寸16cm×13cm×20cm；

產(chǎn)地：美國

文獻案例：

在2016年已發(fā)表的果蠅有關(guān)文獻中，使用SSI果蠅代謝監(jiān)測系統(tǒng)的達(dá)14篇，2015年11篇，截止目前相關(guān)文獻共計500多篇。

1. Andrew N R, Ghaedi B, Groenewald B. The role of nest surface temperatures and the brain in influencing ant metabolic rates[J]. Journal of Thermal Biology, 2016, 60: 132-139.

2. Baaren J, Dufour C M S, Pierre J S, et al. Evolution of life‐history traits and mating strategy in males: a case study on two populations of a Drosophila parasitoid[J]. Biological Journal of the Linnean Society, 2016, 117(2): 231-240.

3. Bartholomew N R, Burdett J M, VandenBrooks J M, et al. Impaired climbing and flight behaviour in Drosophila melanogaster following carbon dioxide anaesthesia[J]. Scientific reports, 2015, 5.

4. Basson C H, Clusella-Trullas S. The behavior-physiology nexus: behavioral and physiological compensation are relied on to different extents between seasons[J]. Physiological and Biochemical Zoology, 2015, 88(4): 384-394.

5. Bosco G, Clamer M, Messulam E, et al. EFFECTS OF OXYGEN CONCENTRATION AND PRESSURE ON Drosophila melanogaster: OXIDATIVE STRESS, MITOCHONDRIAL ACTIVITY, AND SURVIVORSHIP[J]. Archives of insect biochemistry and physiology, 2015, 88(4): 222-234.

6. Casas J, Body M, Gutzwiller F, et al. Increasing metabolic rate despite declining body weight in an adult parasitoid wasp[J]. Journal of insect physiology, 2015, 79: 27-35.

7. Correa Y D C G, Faroni L R A, Haddi K, et al. Locomotory and physiological responses induced by clove and cinnamon essential oils in the maize weevil Sitophilus zeamais[J]. Pesticide biochemistry and physiology, 2015, 125: 31-37.

8. DeVries Z C, Kells S A, Appel A G. Estimating the critical thermal maximum (CT max) of bed bugs, Cimex lectularius: Comparing thermolimit respirometry with traditional visual methods[J]. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2016, 197: 52-57.

9. Dreiss A N, Séchaud R, Béziers P, et al. Social huddling and physiological thermoregulation are related to melanism in the nocturnal barn owl[J]. Oecologia, 2016, 180(2): 371-381.

10. Duun Rohde P, Krag K, Loeschcke V, et al. A Quantitative Genomic Approach for Analysis of Fitness and Stress Related Traits in a Drosophila melanogaster Model Population[J]. International Journal of Genomics, 2016, 2016.

11. Fischer K E, Gelfond J A L, Soto V Y, et al. Health effects of long-term rapamycin treatment: the impact on mouse health of enteric rapamycin treatment from four months of age throughout life[J]. PloS one, 2015, 10(5): e0126644.

12. Groom D J E, Toledo M C B, Welch K C. Wingbeat kinematics and energetics during weightlifting in hovering hummingbirds across an elevational gradient[J]. Journal of Comparative Physiology B, 2016: 1-18.

13. Gudowska A, Boardman L, Terblanche J S. The closed spiracle phase of discontinuous gas exchange predicts diving duration in the grasshopper, Paracinema tricolor[J]. Journal of Experimental Biology, 2016: jeb. 135129.

14. Haddi K, Mendes M V, Barcellos M S, et al. Sexual Success after Stress? Imidacloprid-Induced Hormesis in Males of the Neotropical Stink Bug Euschistus heros[J]. PloS one, 2016, 11(6): e0156616.

15. Haddi K, Oliveira E E, Faroni L R A, et al. Sublethal exposure to clove and cinnamon essential oils induces hormetic-like responses and disturbs behavioral and respiratory responses in Sitophilus zeamais (Coleoptera: Curculionidae)[J]. Journal of economic entomology, 2015: tov255.

16. Horváthová T, Antol A, Czarnoleski M, et al. Does temperature and oxygen affect duration of intramarsupial development and juvenile growth in the terrestrial isopod Porcellio scaber (Crustacea, Malacostraca)?[J]. ZooKeys, 2015 (515): 67.

17. Kivel? S M, Lehmann P, Gotthard K. Do respiratory limitations affect metabolism of insect larvae before moulting: an empirical test at the individual level[J]. Journal of Experimental Biology, 2016: jeb. 140442.

18. Lebeau J, Wesselingh R A, Van Dyck H. Nectar resource limitation affects butterfly flight performance and metabolism differently in intensive and extensive agricultural landscapes[C]//Proc. R. Soc. B. The Royal Society, 2016, 283(1830): .

19. MacMillan H A, Schou M F, Kristensen T N, et al. Preservation of potassium balance is strongly associated with insect cold tolerance in the field: a seasonal study of Drosophila subobscura[J]. Biology letters, 2016, 12(5): .

20. Meyers P J, Powell T H Q, Walden K K O, et al. Divergence of the diapause transcriptome in apple maggot flies: winter regulation and post-winter transcriptional repression[J]. Journal of Experimental Biology, 2016: jeb. 140566.

21. Plav?in I, Sta?ková T, ?ery M, et al. Hormonal enhancement of insecticide efficacy in Tribolium castaneum: Oxidative stress and metabolic aspects[J]. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2015, 170: 19-27.

22. Rodrigues C G, Krüger A P, Barbosa W F, et al. Leaf Fertilizers Affect Survival and Behavior of the Neotropical Stingless Bee Friesella schrottkyi (Meliponini: Apidae: Hymenoptera)[J]. Journal of economic entomology, 2016, 109(3): 1001-1008.

23. Thienel M, Canals M, Bozinovic F, et al. The effects of temperature on the gas exchange cycle in Agathemera crassa[J]. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2015, 183: 126-130.

24. Williams C M, Chick W D, Sinclair B J. A cross‐seasonal perspective on local adaptation: metabolic plasticity mediates responses to winter in a thermal‐generalist moth[J]. Functional Ecology, 2015, 29(4): 549-561.

25. Williams C M, Szejner-Sigal A, Morgan T J, et al. Adaptation to Low Temperature Exposure Increases Metabolic Rates Independently of Growth Rates[J]. Integrative and comparative biology, 2016: icw009.